Auto-disable syringe has a mechanism to immobilize the plunger or block the needle or cause the syringe to leak when a second injection is attempted hence it cannot be reused. The needle is also fixed permanently in the syringe to prevent the reuse of the needle as well. Mandatory use of auto-disable syringes for vaccination is a good step for ensuring injection safety. But associated cost and safe disposal is a serious limitation for developing countries. Although auto-disable syringe cannot be reused, the exposed needle can be risky. Moreover disposal of auto-disable syringe is also a challenge in developing countries where the infrastructure for disposal is lacking. Despite the growing awareness about the need of safe health care waste management (including disposal of injectable), compliance is lacking.[[url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643353/#ref4]4[/url]] So, pros and cons of each intervention, in context to the implementation region and resources should be analysed before implementation.